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    Matthew G. Kestenbaum, MD, Agustin O. Connor, PhD, Perry G. A major goal of palliative care is to provide comfort, and pain is one of the most common causes of treatable suffering in patients with advanced disease. Opioids are indispensable for pain management in palliative care and can usually be provided by the oral route, which is safe, effective, and of lowest cost in most cases.
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    Keep the medication in a place where others cannot get to it. Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Buprenorphine is an opioid medication.
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    Exploring the unconventional routes — rectal and vaginal dosage formulations

    Keep the medication in a place where others cannot get to it. Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Buprenorphine and naloxone is a combination medicine used to treat opioid addiction.
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    The rectum and vagina are relatively uncommon routes for drug administration. However, they can be ideal sites for drug delivery when it comes to certain diseases and patient groups. The rectal route, for example, can be useful in paediatric and geriatric groups, and in patients who are unable to take oral medicines due to nausea, vomiting or unconsciousness.
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